Onchocerca volvulus-microfilariae avoid complement attack by direct binding of factor H
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منابع مشابه
Onchocerca volvulus microfilariae avoid complement attack by direct binding of factor H.
The filarial parasite Onchocerca volvulus is the causative agent of river blindness. The adult worms produce microfilariae (mf), which are responsible for the disease pathogenesis; mf activate the complement system, but the activation stops before the formation of terminal complement complexes. Because of the arrest of complement activation, this study analyzed binding of the main alternative p...
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Microfilariae of Onchocerca volvulus from Guatemala were examined by scanning electron microscope. There are numerous transverse striations on the cuticular surface. The number of annulations varies from 325 to 357. The anterior end forms a round cephalic cap which bears a V-shaped hook. Two small openings are present on the cephalic cap. They are probably the openings of one of the amphidial c...
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Onchocerciasis is a major cause of blindness worldwide, and much of the blindness is caused by onchocercal chorioretinitis. In an experimental animal model for ocular onchocerciasis, intravitreal injections of 10,000 live Onchocerca volvulus microfilariae isolated from infected humans into the eyes of cynomolgus monkeys (Macaca fascicularis) resulted in patchy, progressive loss of retinal pigme...
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Exposure of nonself surfaces such as those of biomaterials or transplanted cells and organs to host blood frequently triggers innate immune responses, thereby affecting both their functionality and tolerability. Activation of the alternative pathway of complement plays a decisive role in this unfavorable reaction. Whereas previous studies demonstrated that immobilization of physiological regula...
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There is no published account which allows the morphological discrimination of microfilariae of Onchocerca volvulus and M. ozzardi from each other. However, they occur together in parts of Brazil and Venezuela, and presumably there is always the possibility that migration could establish new sympatric populations in the future. The objective of this study was to evaluate simple morphological ch...
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ژورنال
عنوان ژورنال: Immunopharmacology
سال: 2000
ISSN: 0162-3109
DOI: 10.1016/s0162-3109(00)80161-7